hyperosmolar hyperglycemic nonketotic syndrome (HY-per-oz-MOH-lur HY-per-gly-SEE-mik non-kee-TAH-tik) (HHNS): an emergency condition in which one’s blood glucose level is very high and ketones are not present in the blood or urine. If HHNS is not treated, it can lead to coma or death.